University of Queensland scientists close in on first dengue treatment
Clinical trials for a dengue fever treatment could start within a year, following a discovery by University of Queensland scientists.
UQ’s School of Chemistry and Molecular Biosciences Head Professor Paul Young said the researchers had identified similarities in how the body reacted to dengue virus and bacterial infections, in a finding that would allow them to re-purpose existing drugs.
“We have discovered that the dengue virus NS1 protein acts as a toxin in the body, in a similar manner to the way bacterial cell wall products lead to septic shock in bacterial infections,” he said.
“For the past 20 to 30 years, researchers and pharmaceutical companies have been developing drug candidates to inhibit the body’s damaging responses to these bacterial infections.
“So drugs are already available that have gone through phase three clinical trials.
Professor Young said mosquito-borne dengue virus was an increasing problem in tropical and sub-tropical areas, with more than 2.5 billion people in more than 100 countries at risk of infection.
Dengue virus is estimated to infect up to 400 million people globally each year. The World Health Organisation ranks it as the most important mosquito-borne viral disease in the world.
he UQ research group’s findings and the availability of drugs already developed for bacterial infections mean that clinical testing could begin in as little as one to two years.
Members of the UQ research team are Professor Paul Young, PhD student Naphak Modhiran, Associate Professor Kate Stacey and Dr Dan Watterson.
The research, conducted in UQ’s School of Chemistry and Molecular Biosciences and the Australian Infectious Disease Research Centre, is published in Science Translational Medicine