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Eli Lilly says it has potential to launch 20 new products in 10 years

Eli Lilly says it has potential to launch 20 new products in 10 years

In a presentation to the investment community, Eli Lilly and Company stated it has the potential to launch 20 new products in the 10 years beginning in 2014 and extending through 2023.

In addition, Lilly could launch an average of two new indications or line extensions for already-approved products per year during that same time period.

“We’re pleased to share with investors the breadth and depth of the Lilly pipeline, which showcases our progress across our key therapeutic areas. This includes recent launches as well as a robust lineup of assets in late-stage development or already under regulatory review,” said John C. Lechleiter, Ph.D., Lilly’s chairman, president and chief executive officer.

“There are no guarantees given the nature of science and of our business; however, in looking at our recent launches and current pipeline, we believe we are in the midst of the most prolific period of new launches in our company’s 140-year history.”

Lilly’s R&D efforts focus on five therapeutic areas where the company has assets and capabilities that enable it to compete successfully. These include four core areas — diabetes, oncology, immunology and neurodegeneration — and one emerging area — pain.

Building upon a similar investment community meeting in December 2015 focused on neurodegeneration – specifically Alzheimer’s disease – as well as animal health, today’s presentation highlighted the company’s R&D strategy and progress in diabetes, oncology, immunology and pain.

“We have improved the productivity and success of our pipeline through discrete actions aimed at enhancing focus, quality and speed, and by positioning ourselves as an attractive partner for external innovation opportunities,” said Jan Lundberg, Ph.D., executive vice president of science and technology and president of Lilly Research Laboratories.

“These improvements have led to the potential for unprecedented R&D output.”

Diabetes

Lilly’s long-standing commitment to diabetes care dates to 1923, when it was the first company to bring insulin to patients. Today, the company has the broadest range of diabetes therapies in the industry. Lilly’s R&D efforts in diabetes focus on differentiated therapeutics and delivery devices within three key areas of unmet need: glucose control, metabolic control and end-organ protection. The company aims to combine its strong in-house diabetes R&D capabilities with a comprehensive external network to deliver continued innovation in this important area of therapy.

Oncology

Lilly has a long history of leadership in oncology. The company has a balanced R&D approach across three key areas of disease modification: tumor cell signaling, tumor microenvironment and immuno-oncology. This approach allows for testing of combinations of internally-derived agents to address tumor heterogeneity and drug resistance. Lilly has a portfolio of differentiated assets across these approaches, including Cyramza (ramucirumab), Portrazza (necitumumab), olaratumab and abemaciclib. Lilly’s immuno-oncology portfolio will have five differentiated molecules in clinical testing by the end of 2016, and as many as 11 by the end of 2018.

Immunology

With the recent launch of Taltz (ixekizumab) and the submission of baricitinib for regulatory review, Lilly has designated immunology as the company’s newest core therapeutic area. While these assets represent the foundational first wave of innovation, Lilly has built a robust emerging pipeline of both internal assets and partnered molecules focusing on key pathways and interventions in multiple autoimmune diseases.

Neurodegeneration

Lilly’s commitment to Alzheimer’s disease is demonstrated by its more than 25 years of research and development in the field. As a result of this sustained effort and deep understanding of the disease, Lilly today has one of the industry’s most comprehensive Alzheimer’s portfolios, with seven molecules already in human testing. The company’s Alzheimer’s research includes disease prevention, detection and treatment.

Pain

Pain is an emerging research area for Lilly, focusing on non-opioid treatment for chronic pain. The two late-stage innovative medicines currently in development are galcanezumab (CGRP Ab), being studied for cluster headache and migraine, and tanezumab, being studied for osteoarthritis pain, chronic lower back pain and cancer pain in partnership with Pfizer.

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